Sex difference in bronchopulmonary dysplasia of offspring in response to maternal PM exposure.

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ID: 90058
2020
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Abstract
The adverse effects of fine particulate matters (PM) on respiratory diseases start in utero. In order to investigate whether maternal PM exposure could lead to bronchopulmonary dysplasia (BPD) in offspring, PM was collected in Taiyuan, Shanxi, China during the annual heating period. Mice were mated and gestation day 0 (GD0) was considered the day on which a vaginal plug was observed. The plug-positive mice received 3 mg/kg b.w. PM by oropharyngeal aspiration every other day starting on GD0 and throughout the gestation period. Offspring were sacrificed at postnatal days (PNDs) 1, 7, 14 and 21. We assessed some typical BPD-like symptoms in offspring. The results showed that maternal PM exposure caused low birth weight, hypoalveolarization, decreased angiogenesis, suppressed production of secretory and surfactant proteins, and increased inflammation in the lungs of male offspring. However, maternal PM exposure induced only hypoalveolarization and inflammation in the lungs of female offspring. Furthermore, these alterations were reversed during postnatal development. Our results demonstrated that maternal exposure to PM caused reversible BPD-related consequences in offspring, and male offspring were more sensitive than females. However, these alterations were reversed during postnatal development.
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yue2020sexjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yue, Huifeng;Ji, Xiaotong;Ku, Tingting;Li, Guangke;Sang, Nan;
Journal Journal of hazardous materials
Year 2020
DOI
S0304-3894(20)30019-4
URL
Keywords
bronchopulmonary dysplasia sex difference low birth weight maternal pm(2.5) exposure

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