Endoplasmic reticulum stress, an important factor in the development of Parkinson's disease.

Clicks: 352
ID: 88226
2020
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Abstract
Similar to other types of neuronal degeneration, Parkinson's disease (PD) is characterized by the aggregation of a pathological protein, α-synuclein. The endoplasmic reticulum (ER) is the principal site of protein synthesis, quality control and degradation. Genetic mutants, environmental insults and other factors disturb ER balance and induce the accumulation of misfolded/unfolded proteins, which initiate ER stress and disturb normal cell function. ER stress perturbs Ca homeostasis and initiates the activation of autophagy and inflammasomes, which have been identified as risk factors for the development of PD. However, the mechanisms by which ER stress contributes to the processed of PD pathogenesis and development remain unclear. This review summarizes current knowledge of ER stress and highlights the principal role of ER stress in PD pathogenesis which may help reveal novel sight to illustrate the pathomechanism of PD.
Reference Key
mou2020endoplasmictoxicology Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Mou, Zheng;Yuan, Yu-He;Zhang, Zhao;Song, Lian-Kun;Chen, Nai-Hong;
Journal toxicology letters
Year 2020
DOI
S0378-4274(20)30027-8
URL
Keywords
endoplasmic reticulum stress neuroinflammation parkinson’s disease hormesis compound

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