A helitron-induced RabGDIα variant causes quantitative recessive resistance to maize rough dwarf disease.

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2020
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Abstract
Maize rough dwarf disease (MRDD), caused by various species of the genus Fijivirus, threatens maize production worldwide. We previously identified a quantitative locus qMrdd1 conferring recessive resistance to one causal species, rice black-streaked dwarf virus (RBSDV). Here, we show that Rab GDP dissociation inhibitor alpha (RabGDIα) is the host susceptibility factor for RBSDV. The viral P7-1 protein binds tightly to the exon-10 and C-terminal regions of RabGDIα to recruit it for viral infection. Insertion of a helitron transposon into RabGDIα intron 10 creates alternative splicing to replace the wild-type exon 10 with a helitron-derived exon 10. The resultant splicing variant RabGDIα-hel has difficulty being recruited by P7-1, thus leading to quantitative recessive resistance to MRDD. All naturally occurring resistance alleles may have arisen from a recent single helitron insertion event. These resistance alleles are valuable to improve maize resistance to MRDD and potentially to engineer RBSDV resistance in other crops.
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Authors Liu, Qingcai;Deng, Suining;Liu, Baoshen;Tao, Yongfu;Ai, Haiyue;Liu, Jianju;Zhang, Yongzhong;Zhao, Yan;Xu, Mingliang;
Journal Nature communications
Year 2020
DOI
10.1038/s41467-020-14372-3
URL
Keywords
heterogeneity cross-sectional dependence energy-growth nexus local energy policies shale gas the us economy

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