Gas Chromatography-Mass Spectrometry Profiling of Volatile Compounds Reveals Metabolic Changes in a Non-Aflatoxigenic Induced by 5-Azacytidine.

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ID: 87022
2020
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Abstract
is one of the most opportunistic pathogens invading many important oilseed crops and foodstuffs with such toxic secondary metabolites as aflatoxin (AF) and Cyclopiazonic acid. We previously used the DNA methylation inhibitor 5-azacytidine to treat with an AF-producing A133 strain, and isolated a mutant (NT) of , which displayed impaired abilities of AF biosynthesis and fungal development. In this study, gas chromatography-mass spectrometry (GC-MS) analysis was used to reveal the metabolic changes between these two strains. A total of 1181 volatiles were identified in these two strains, among which 490 volatiles were found in these two strains in vitro and 332 volatiles were found in vivo. The NT mutant was found to produce decreasing volatile compounds, among which most of the fatty acid-derived volatiles were significantly downregulated in the NT mutant compared to the A133 strain, which are important precursors for AF biosynthesis. Two antioxidants and most of the amino acids derived volatiles were found significantly upregulated in the NT mutant. Overall, our results reveal the difference of metabolic profiles in two different isolates, which may provide valuable information for controlling infections of this fungal pathogen.
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song2020gastoxins Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Song, Fengqin;Geng, Qingru;Wang, Xuewei;Gao, Xiaoqing;He, Xiaona;Zhao, Wei;Lan, Huahui;Tian, Jun;Yang, Kunlong;Wang, Shihua;
Journal Toxins
Year 2020
DOI
E57
URL
Keywords
aflatoxin dna methylation aspergillus flavus volatiles

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