Screening Key Genes Associated with the Development and Progression of Non-small Cell Lung Cancer Based on Gene-enrichment Analysis and Meta-analysis

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ID: 85043
2012
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Abstract
Background and objective Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors; however, its causes are still not completely understood. This study was designed to screen the key genes and pathways related to NSCLC occurrence and development and to establish the scientific foundation for the genetic mechanisms and targeted therapy of NSCLC. Methods Both gene set-enrichment analysis (GSEA) and meta-analysis (meta) were used to screen the critical pathways and genes that might be corretacted with the development and progression of lung cancer at the transcription level. Results Using the GSEA and meta methods, focal adhesion and regulation of actin cytoskeleton were determined to be the more prominent overlapping significant pathways. In the focal adhesion pathway, 31 genes were statistically significant (P<0.05), whereas in the regulation of actin cytoskeleton pathway, 32 genes were statistically significant (P<0.05). Conclusion The focal adhesion and the regulation of actin cytoskeleton pathways might play important roles in the occurrence and development of NSCLC. Further studies are needed to determine the biological function for the positiue genes.
Reference Key
he2012screeningchinese Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors HE, Wenwu;XIAN, Lei;WANG, Yongyong;HU, Yanling;CHEN, Mingwu;
Journal chinese journal of lung cancer
Year 2012
DOI
DOI not found
URL
http://dx.doi.org/10.3779/j.issn.1009-3419.2012.07.05
Keywords
chemistry Biology (General) Medicine Science psychology neoplasms. tumors. oncology. including cancer and carcinogens plant culture genetics

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