In Vitro Evaluation of the Potential Use of Propolis as a Multitarget Therapeutic Product: Physicochemical Properties, Chemical Composition, and Immunomodulatory, Antibacterial, and Anticancer Properties

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ID: 84231
2019
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Abstract
Propolis is a resin that honeybees produce by mixing saliva and beeswax with exudate gathered from botanical sources. The present in vitro study investigated the potential use of propolis as a multitarget therapeutic product and the physicochemical properties, chemical composition, and immunomodulatory, antioxidant, antibacterial, and anticancer properties of a propolis extract from the northern Morocco region (PNM). Pinocembrin, chrysin, and quercetin were the main phenolic compounds of PNM as measured in HPLC. The PNM showed significant inhibitory effects against all tested Gram-positive and Gram-negative strains and showed high antioxidant activities by scavenging free radicals with IC50 (DPPH = 0.02, ABTS = 0.04, and FRAP = 0.04 mg/ml). In addition, PNM induced a dose-dependent cytostatic effect in MCF-7, HCT, and THP-1 cell lines at noncytotoxic concentrations with IC50 values of 479.22, 108.88, and 50.54 μg/ml, respectively. The production of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) was decreased in a dose-dependent manner in LPS-stimulated human peripheral blood mononuclear cells (PBMNCs), whereas the production of the anti-inflammatory interleukin-10 (IL-10) was increased in a dose-dependent manner reaching 15-fold compared to the levels measured in untreated PBMNCs. Overall, the results showed that the traditionally known multitarget therapeutic properties of the PNM seem to be mediated, at least in part, through cytostatic, antibacterial, and immunomodulatory effects.
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touzani2019inbiomed Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Touzani, Soumaya;Embaslat, Walaa;Imtara, Hamada;Kmail, Abdalsalam;Kadan, Sleman;Zaid, Hilal;ElArabi, Ilham;Badiaa, Lyoussi;Saad, Bashar;
Journal BioMed research international
Year 2019
DOI
DOI not found
URL
http://dx.doi.org/10.1155/2019/4836378
Keywords
chemistry Organic Chemistry Education Biology (General) Botany Medicine Materials of engineering and construction. Mechanics of materials Diseases of the circulatory (Cardiovascular) system neoplasms. tumors. oncology. including cancer and carcinogens cytology islam. bahai faith. theosophy, etc. philosophy. psychology. religion

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