Edible unclonable functions.

Clicks: 318
ID: 83337
2020
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Ranked #105 of 485 articles by views in Nature communications

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Abstract
Counterfeit medicines are a fundamental security problem. Counterfeiting medication poses a tremendous threat to patient safety, public health, and the economy in developed and less developed countries. Current solutions are often vulnerable due to the limited security levels. We propose that the highest protection against counterfeit medicines would be a combination of a physically unclonable function (PUF) with on-dose authentication. A PUF can provide a digital fingerprint with multiple pairs of input challenges and output responses. On-dose authentication can verify every individual pill without removing the identification tag. Here, we report on-dose PUFs that can be directly attached onto the surface of medicines, be swallowed, and digested. Fluorescent proteins and silk proteins serve as edible photonic biomaterials and the photoluminescent properties provide parametric support of challenge-response pairs. Such edible cryptographic primitives can play an important role in pharmaceutical anti-counterfeiting and other security applications requiring immediate destruction or vanishing features.
Reference Key
leem2020ediblenature Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Leem, Jung Woo;Kim, Min Seok;Choi, Seung Ho;Kim, Seong-Ryul;Kim, Seong-Wan;Song, Young Min;Young, Robert J;Kim, Young L;
Journal Nature communications
Year 2020
DOI
10.1038/s41467-019-14066-5
URL
Keywords
rats flow cytometry bone marrow genotoxicity micronucleus test

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