Gambir Extract () Decreases Inflammatory Response and Increases Gastric Mucosal Integrity in Wistar Rats - Model Gastritis.

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ID: 82472
2019
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Abstract
(local name: gambir) is a plant native to Sumatera, Malaya and Borneo. This plant is potential as local wisdom for therapeutics. In Sumatera, gambir was used as a traditional treatment for fever, diarrhoea, diabetics and wound healing.To explore the efficacy of gambir extract on TNF alpha level, prostaglandin E2 level, lesson area, body weight, lipid profile and leptin level in Wistar rat-model gastritis.This study was an experimental study, with a pre-post-test control group design. The subjects in this study were 30 male rats, 8 weeks old, weight 150-200 gram. Rats were administered with gambir extract at the dose of 20, 40 and 80 mg/kg BW/day for 3 days. Gambir was extracted by maceration methods. Statistical analysis was performed by SPSS 18.Gambir extract at the dose of 80 mg/kg BW exhibited the highest efficacy in reducing TNF alpha level, lesion area and increasing prostaglandin E2 level compared to gambir extract at doses of 20 mg/kg BW, 400 mg/kg BW, negative control, and positive control.Gambir extract was effective in reducing TNF alpha level, lesson area, and increasing prostaglandin E2 level in Wistar rat-model gastritis.
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oswari2019gambiropen Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Oswari, Liniyati;Hidayat, Rachmat;Fatmawati, Fatmawati;Hayati, Lusia;Alisa, Bella Safira;
Journal open access macedonian journal of medical sciences
Year 2019
DOI
10.3889/oamjms.2019.758
URL
Keywords
prostaglandin e2 tnf alpha gastritis gambir extract uncaria gambir

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