Wound dressing from polyvinyl alcohol/chitosan electrospun fiber membrane loaded with OH-CATH30 nanoparticles.
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ID: 82465
2020
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Abstract
Novel nanomaterials have been developed for antimicrobial and wound healing applications. Here, we report the preparation of a polyvinyl alcohol/chitosan (PVA/CS) nanofiber with carboxymethyl chitosan nanoparticles (CMCS-OH30 NPs) encapsulating the antibacterial peptide OH-CATH30 (OH-30). The PVA/CS nanofibers containing OH-30 NPs (NP-30-NFs) obtained via electrospinning could achieve a secondary embedded OH-30. The effect of NP-30-NFs on the release of OH-30 was investigated through high-performance liquid chromatography. The antibacterial activities of NP-30-NFs against Escherichia coli and Staphylococcus aureus were studied by bacterial plate counting. NP-30-NFs containing different concentrations of NPs were applied to mouse skin wounds to determine their effectiveness in promoting wound healing. Results showed that NP-30-NFs exhibited antibacterial properties and promoted skin wound healing.
| Reference Key |
zou2020woundcarbohydrate
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|---|---|
| Authors | Zou, Pengfei;Lee, Wen-Hui;Gao, Zhiqin;Qin, Di;Wang, Yuxia;Liu, Jiao;Sun, Tongyi;Gao, Yuanyuan; |
| Journal | Carbohydrate polymers |
| Year | 2020 |
| DOI |
S0144-8617(19)31454-7
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