Fetal and postnatal metal dysregulation in autism.

Clicks: 311
ID: 82088
2017
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Popular

Ranked #110 of 485 articles by views in Nature communications

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 485 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Genetic and environmental factors contribute to the etiologies of autism spectrum disorder (ASD), but evidence of specific environmental exposures and susceptibility windows is limited. Here we study monozygotic and dizygotic twins discordant for ASD to test whether fetal and postnatal metal dysregulation increases ASD risk. Using validated tooth-matrix biomarkers, we estimate pre- and post-natal exposure profiles of essential and toxic elements. Significant divergences are apparent in metal uptake between ASD cases and their control siblings, but only during discrete developmental periods. Cases have reduced uptake of essential elements manganese and zinc, and higher uptake of the neurotoxin lead. Manganese and lead are also correlated with ASD severity and autistic traits. Our study suggests that metal toxicant uptake and essential element deficiency during specific developmental windows increases ASD risk and severity, supporting the hypothesis of systemic elemental dysregulation in ASD. Independent replication in population-based studies is needed to extend these findings.
Reference Key
arora2017fetalnature Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Arora, Manish;Reichenberg, Abraham;Willfors, Charlotte;Austin, Christine;Gennings, Chris;Berggren, Steve;Lichtenstein, Paul;Anckarsäter, Henrik;Tammimies, Kristiina;Bölte, Sven;
Journal Nature communications
Year 2017
DOI
10.1038/ncomms15493
URL
Keywords
microrna methylation brain long noncoding rna transposons

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.