Cobalt-Catalyzed Intermolecular Markovnikov Hydroamination of Nonactivated Olefins: -Selective Alkylation of Benzotriazole.

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ID: 81875
2020
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Abstract
Cobalt-catalyzed Markovnikov-selective hydroamination of nonactivated olefins was developed. Hydrogen atom transfer from a catalytically generated cobalt(III)-hydride complex to the olefins proceeded regioselectively, and the nucleophilic addition of benzotriazoles occurred selectively at their -positions. The synthetic utility of the obtained -alkylated benzotriazoles as stable amine protecting groups under various reaction conditions was demonstrated, and the products were also transformed into primary amines by zinc-mediated reduction.
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yahata2020cobaltcatalyzedorganic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yahata, Kenzo;Kaneko, Yuki;Akai, Shuji;
Journal Organic letters
Year 2020
DOI
10.1021/acs.orglett.9b04375
URL
Keywords
inhibitor conjugate amino acid carbonic anhydrase sulphonamide

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