Bio-active sesquiterpenoids and norsesquiternoids from the Red Sea octocoral .

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ID: 80564
2019
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Abstract
Three previously undescribed nardosinane-type sesquiterpenes (-), together with six known compounds (-) were isolated from the alcyonacean soft coral and are 13-nornardosinane, and 6,7-seco-13-nornardosinane derivatives, respectively. could be an artifact due to C-6 epimerization of the known one . Chemical structures were elucidated based on 1 D, 2 D NMR and MS spectral data. Compounds - showed cytotoxic activity against NCI-H1299, HepG2 and MCF-7 with IC values between 0.0352-0.0974, 0.0717-0.3745 and 0.0341-0.1325 mM, respectively. The antibacterial activity of all isolated compounds have examined against a number of Gram-positive (, ) and Gram-negative (, and sp.) bacteria. Compounds and showed a high degree of inhibition against and sp. Interestingly, neolemnane ( showed strong inhibition against two fungi, and ; while showed positive inhibition against at 150 µg/mL.
Reference Key
ayyad2019bioactivenatural Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ayyad, Seif-Eldin Nasr;Deyab, Mohamed Ali;Kosbar, Tamer;Alarif, Walied Mohamed;Eissa, Ahmed Hassan;
Journal Natural product research
Year 2019
DOI
10.1080/14786419.2019.1709187
URL
Keywords
Antimicrobial sesquiterpenes red sea cytotoxic soft coral

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