Encapsulation of β-alanine model amino-acid in zirconium(IV) metal organic frameworks: Defect engineering to improve host guest interactions.

Clicks: 358
ID: 80273
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #11 of 119 articles by views in Journal of inorganic biochemistry

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Metal-Organic Frameworks (MOFs) are porous coordination networks assembled through metal complexes with organic linkers. Due to their chemical versatility, these materials are being investigated for various applications including gas storage and separation, biomedicine and catalysis. The aim of this work is the encapsulation of the model β-alanine amino-acid in the nanostructured zirconium-based MOF (UiO-66) which contains the ligand HBDC (1,4-benzenedicaboxylic acid). Additionally, ligand functionalization (by using HdoBDC (2,5-dihydroxy-1,4-benzenedicarboxylic acid) and defect engineering have been carried out to produce UiO-66 derivatives, in order to modify the host-guest interactions, and hence study their influence on the β-alanine loading capacity and release kinetics. The as-obtained materials have been characterized by X-ray diffraction (XRD), X-ray thermo diffraction (TDX), infrared (IR) spectroscopy, thermogravimetric analysis-differential scanning calorimetry (TG-DSC) and elemental analysis (EA). Morphology of nanoscale MOFs has been explored by transition electron microscopy (TEM). Adsorption isotherms have been constructed, and the concentration of β-alanine in the post-adsorption solution (supernatant) has been quantified by high performance liquid chromatography coupled with mass spectroscopy (HPLC-MS) and EA. Adsorption capacity values indicate that the presence of hydroxyl groups at the organic linker HdoBDC enhances the host-guess affinity between the framework and the adsorbate β-alanine. The influence of defect engineering, on the adsorption however, is not that obvious. On the other hand, desorption experiments show similar behaviour for HdoBDC-based derivatives. An adsorption mechanism has been proposed consisting of a combination of host-guest interaction at low concentrations, and covalent anchoring/ligand displacement by β-alanine at the inorganic clusters.
Reference Key
muguruza2019encapsulationjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Muguruza, Asier R;de Luis, Roberto Fernandez;Iglesias, Naroa;Bazán, Begoña;Urtiaga, Miren-Karmele;Larrea, Edurne S;Fidalgo-Marijuan, Arkaitz;Barandika, Gotzone;
Journal Journal of inorganic biochemistry
Year 2019
DOI
S0162-0134(19)30475-1
URL
Keywords
encapsulation drug delivery systems β-alanine defect engineering host-guest interactions zirconium(iv)-based metal organic frameworks

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.