Radiotherapy for local recurrence of non-small-cell lung cancer after lobectomy and lymph node dissection-can local recurrence be radically cured by radiation?

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ID: 79680
2020
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Abstract
There is no standard therapeutic approach for local recurrence of non-small cell lung cancer (NSCLC) after complete resection. We investigated the outcomes of radiotherapy (RT) for patients with local recurrence.We reviewed 46 patients who underwent curative-intent RT for local recurrence after lobectomy or pneumonectomy accompanied with mediastinal lymph node dissection between 2002 and 2014. We analyzed overall survival (OS), progression-free survival (PFS), local control, tumour response and the re-recurrence pattern.Among the 46 patients, 16 received concurrent chemotherapy. The median follow-up period was 48 months. The response rate was 91%. The 5-year OS and local control rates were 47.9 and 65.3%, respectively, and the 5-year PFS rate was 22.8%. Female sex and complete response to radiation were favourable prognostic factors. Of the 33 patients with recurrence after radiation, 32 (97%) had distant metastasis.Although RT for local recurrence has high efficacy, distant relapse after radiation remains a major issue. Therefore, combination systemic therapy for local recurrence at any site should be further investigated. Since it is difficult to achieve a radical cure for local recurrence using RT, further study, for the administration of post-operative adjuvant therapy, is recommended.
Reference Key
terada2020radiotherapyjapanese Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yukihiro Terada, Mitsuhiro Isaka, Hideyuki Harada, Hayato Konno, Hideaki Kojima, Tetsuya Mizuno, Shigeyuki Murayama, Toshiaki Takahashi, Yasuhisa Ohde
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Journal japanese journal of clinical oncology
Year 2020
DOI
hyz188
URL
Keywords
chemoradiotherapy complete resection neoplasm metastasis neoplasm recurrence non-small cell lung carcinoma

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