Mequindox induces apoptosis, DNA damage, and carcinogenicity in Wistar rats.

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ID: 79448
2019
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Ranked #15 of 54 articles by views in food and chemical toxicology : an international journal published for the british industrial biological research association

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Abstract
Mequindox (MEQ) is a synthetic antibacterial agent. Recent studies showed that MEQ and its primary metabolites exhibit strong genotoxicity to mammalian cells, and MEQ induced carcinogenicity in mice. These findings suggest that chronic exposure to MEQ could lead to an increased risk of cancer later in life. In the present study, four groups of Wistar rats (55 rats/sex/group) were fed with diets containing MEQ (0, 25, 55, and 110 mg/kg) for 2 years. The results showed that the hematological system, liver, kidneys, and adrenal glands, as well as the developmental and reproductive systems, were the main targets for MEQ. Liver toxicity mediated by MEQ was associated with apoptosis and the nuclear factor κB (NF-κB) signaling pathway. In addition, MEQ increased the incidence of tumors in rats. Phosphorylated histone H2AX (γ-H2AX) is identified as a biomarker of cellular response to DNA double-strand breaks (DSB). Our data demonstrated that γ-H2AX expression was significantly increased in tumors. Thus, high levels of DSB might be responsible for carcinogenesis in rats, and further investigation is absolutely required to clarify the exact molecular mechanisms for carcinogenicity caused by MEQ in vivo.
Reference Key
liu2019mequindoxfood Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Liu, Qianying;Lei, Zhixin;Gu, Changqin;Guo, Jingchao;Yu, Huiru;Fatima, Zainab;Zhou, Kaixiang;Shabbir, Muhammad A B;Maan, Muhammad Kashif;Wu, Qinghua;Xie, Shuyu;Wang, Xu;Yuan, Zonghui;
Journal food and chemical toxicology : an international journal published for the british industrial biological research association
Year 2019
DOI
S0278-6915(19)30129-2
URL
Keywords
apoptosis dna damage carcinogenicity mequindox γ-h2ax

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