Benwamycins A-G, Trialkyl-Substituted Benzene Derivatives from a Soil-Derived .

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ID: 79274
2020
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Abstract
Seven new trialkyl-substituted benzene derivatives named benwamycins A-G (-), together with three known congeners, -, were isolated from culture broth of the soil-derived sp. KIB-H1471. Their structures were elucidated by using 1D and 2D NMR analyses in combination with HRESIMS data. The absolute configurations of - were determined by chemical conversion and comparison of circular dichroism spectra and confirmed for by single-crystal X-ray crystallography. Compounds and have a unique γ-pyrone-like ring on one side chain. Compounds and inhibited human T cell proliferation with IC values of 14.3 and 12.5 μM, respectively, without obvious cytotoxicity for naïve human T cells. Compounds and could weakly enhance insulin-stimulated glucose uptake.
Reference Key
yang2020benwamycinsjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yang, Feng-Xian;Huang, Jian-Ping;Liu, Zhixiang;Wang, Zhiyan;Yang, Jing;Tang, Jun;Yu, Zhiyin;Yan, Yijun;Kai, Guoyin;Huang, Sheng-Xiong;
Journal Journal of natural products
Year 2020
DOI
10.1021/acs.jnatprod.9b00903
URL
Keywords
antioxidant activity vegetable oil p. ostii seed quality unsaturated fatty acids

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