Pyrrolopyrazoles: Synthesis, Evaluation and Pharmacological Screening as Antidepressant Agents.

Pirrolopirazóis: Síntese, Avaliação e Triagem Farmacológica como Agentes Antidepressivos.

Clicks: 363
ID: 77183
2019
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Ranked #18 of 111 articles by views in medicinal chemistry (shariqah (united arab emirates))

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Abstract
Pyrroles and fused pyrroles are of great interest as biologically active compounds, among these activities; antidepressant activity is of special concern.Synthesis of a series of pyrrolopyrazoles and their pyrimidine derivatives and their characterization using spectral data to be monitored for antidepressant activity using behavioral techniques.A control group was administered the vehicle i.p., positive control group received fluoxetine as standard and all other groups were administered the tested compounds. The groups were subjected to tail suspension test (TST) to determine the antidepressant activity compared with fluoxetine as a standard drug. The compounds exhibiting antidepressant activity were then used to analyze changes in serotonin (5HT) level in the brain of albino mice.TST results showed that both pyrazoles and pyrazolopyrimidines derivatives exhibit promising anti-depressant activity.Compounds [pyrazoles & pyrazlopyrimidines] showed promising antidepressant activity possibly mediated by the increased levels of 5HT.
Pirróis e pirróis condensados são de grande interesse como compostos biologicamente ativos; dentre essas atividades, a atividade antidepressiva é de particular relevância. Síntese de uma série de pirrolopirazóis e de seus derivados pirimidínicos e sua caracterização por meio de dados espectrais para avaliação da atividade antidepressiva utilizando técnicas comportamentais. Um grupo controle recebeu o veículo por via i.p., o grupo controle positivo recebeu fluoxetina como padrão e todos os demais grupos receberam os compostos testados. Os grupos foram submetidos ao teste de suspensão pela cauda (TST) para determinar a atividade antidepressiva em comparação com a fluoxetina como fármaco padrão. Os compostos que exibiram atividade antidepressiva foram então utilizados para analisar alterações nos níveis de serotonina (5-HT) no cérebro de camundongos albinos. Os resultados do TST demonstraram que tanto os derivados de pirazol quanto os de pirazolopirimidina exibem atividade antidepressiva promissora. Os compostos [pirazóis e pirazolopirimidinas] apresentaram atividade antidepressiva promissora, possivelmente mediada pelo aumento dos níveis de 5-HT.
Reference Key
fatahala2019pyrrolopyrazolesmedicinal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Fatahala, Samar S;Nofal, Shahira;Mahmoud, Eman;Abd El-Hameed, Rania H;
Journal medicinal chemistry (shariqah (united arab emirates))
Year 2019
DOI
10.2174/1573406414666181108090321
URL
Keywords
pyrazolopyrimidine pyrrole sar anti-depressant assay pyrrolopyrazole synthesis.

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