Ribosomal incorporation of aromatic oligoamides as peptide side-chain appendages.

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ID: 76107
2020
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Abstract
Derivatives of 4-aminomethyl-L-phenylalanine having aromatic oligoamide foldamers as side chain appendages were successfully charged on tRNA by means of flexizymes. Their subsequent ribosomal incorporation both at the C-terminus of, and within, peptide sequences, was demonstrated. These results expand the registry of chemical structures tolerated by the ribosome machinery to side-chains significantly larger and more structurally defined than was previously known.
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tsiamantas2020ribosomalangewandte Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Tsiamantas, Christos;Kwon, Sunbum;Rogers, Joseph Matthew;Douat, Céline;Huc, Ivan;Suga, Hiroaki;
Journal angewandte chemie (international ed in english)
Year 2020
DOI
10.1002/anie.201914654
URL
Keywords
aromatic foldamers flexizyme foldamer-peptide hybrids in vitro translation translation elongation

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