Outcomes of Community-Based Systematic Screening of Household Contacts of Patients with Multidrug-Resistant Tuberculosis in Myanmar.

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ID: 75167
2019
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Abstract
Screening of household contacts of patients with multidrug-resistant tuberculosis (MDR-TB) is a crucial active TB case-finding intervention. Before 2016, this intervention had not been implemented in Myanmar, a country with a high MDR-TB burden. In 2016, a community-based screening of household contacts of MDR-TB patients using a systematic TB-screening algorithm (symptom screening and chest radiography followed by sputum smear microscopy and Xpert-MTB/RIF assays) was implemented in 33 townships in Myanmar. We assessed the implementation of this intervention, how well the screening algorithm was followed, and the yield of active TB. Data collected between April 2016 and March 2017 were analyzed using logistic and log-binomial regression. Of 620 household contacts of 210 MDR-TB patients enrolled for screening, 620 (100%) underwent TB symptom screening and 505 (81%) underwent chest radiography. Of 240 (39%) symptomatic household contacts, 71 (30%) were not further screened according to the algorithm. Children aged <15 years were less likely to follow the algorithm. Twenty-four contacts were diagnosed with active TB, including two rifampicin- resistant cases (yield of active TB = 3.9%, 95% CI: 2.3%-6.5%). The highest yield was found among children aged <5 years (10.0%, 95% CI: 3.6%-24.7%). Household contact screening should be strengthened, continued, and scaled up for all MDR-TB patients in Myanmar.
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kyaw2019outcomestropical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kyaw, Nang Thu Thu;Sithu, Aung;Satyanarayana, Srinath;Kumar, Ajay M V;Thein, Saw;Thi, Aye Myat;Wai, Pyae Phyo;Lin, Yan Naing;Kyaw, Khine Wut Yee;Tun, Moe Myint Theingi;Oo, Myo Minn;Aung, Si Thu;Harries, Anthony D;
Journal Tropical medicine and infectious disease
Year 2019
DOI
E2
URL
Keywords
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