GC-MS profiling, FTIR, metal analysis, antibacterial and anticancer potential of Monotheca buxifolia (Falc.) leaves.

Clicks: 318
ID: 74211
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #17 of 39 articles by views in pakistan journal of pharmaceutical sciences

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Monotheca buxifolia has traditionally been employed in folk medicines to cure of infectious diseases. Current study was aimed to standardize the M. buxifolia leaves extract and evaluate its antibacterial and anticancer activity. Phytochemical analysis was carried through GC, GC/MS, FTIR, and ICP-OES analytical techniques. Antibacterial assay of the crude extract was performed by using tetrazolium micro plates. The extract treated bacteria were observed under (AFM) atomic force microscope and PCR was used for DNA amplification. The anti-proliferative activity of M. buxifolia leaves extract was examined through MTT cytotoxicity assay. The bacterial strains employed in this study were S. epidermidis ATCC (13518), S. aureus ATCC (25923), P. aeruginosa ATCC (10145), and E. coli ATCC (10536). Minimum inhibitory concentration (MIC50) against gram positive bacteria was significantly (p<0.01) achieved at 50 and 75μg/mL. MIC50 against E. coli and P. aeruginosa was also significant at 100μg/mL (p<0.01). M. buxifolia leaves extract damaged the cell walls gram-positive and gram-negative bacteria, while biofilm around gram positive bacteria was significantly damaged. The DNA decantation was also inhibited of S. aureus and S. epidermidis, however, no any impact was observed on E. coli and P. aeruginosa DNA decantation. The cytotoxicity findings suggested that the crude extract of M. buxifolia leaves at 1000μg/mL gives significant inhibition 73.96±2.0%, 83.76±1.2%, 77.66±1.2% and 72.67±1.6% against MDA-MB-231, MCF-7, HeLa and H460 cell lines respectively at (p<0.001). It may be concluded that M. buxifolia leaves extract have significant and promising antibacterial and anti-cancer activities which could be helpful to establish new antimicrobial and anticancer agents.
Reference Key
burki2019gcmspakistan Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Burki, Samiullah;Mehjabeen, -;Burki, Zeba Gul;Jahan, Noor;Muhammad, Shafi;Mohani, Nadeem;Siddiqui, Faheem Ahmed;Owais, Farah;
Journal pakistan journal of pharmaceutical sciences
Year 2019
DOI
DOI not found
URL URL not found
Keywords
vitamin E drug delivery solid lipid nanoparticles (slns) solvent injection-homogenization technique α-tocopherol acetate

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.