Bisphenol A and several derivatives exert neural toxicity in human neuron-like cells by decreasing neurite length.

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ID: 73535
2020
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Ranked #28 of 54 articles by views in food and chemical toxicology : an international journal published for the british industrial biological research association

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Abstract
Bisphenol A (BPA) and its derivatives, including bisphenols S (BPS), F (BPF), E (BPE), B (BPB), Z (BPZ), and AF (BPAF), are widely used in consumer products. Moreover, they are typically detected in the environment, food, and humans. Previous studies have linked BPA to several health risks, but it is still unclear whether BPA replacements are safe. In this study, we developed an in vitro model based on human embryonic stem cells (hESCs) to explore the potential neural toxicity of these compounds. We observed that the bisphenols affected the viability of hESCs and hESC-derived neural stem cells (NSCs) at high concentrations, with BPS being the least cytotoxic and BPAF the strongest cytotoxic compound. At human-relevant concentrations, the bisphenols did not significantly interfere with gene expression and protein levels during hESC differentiation into the neural epithelium, as well as during specification of neuron-like cells from NSCs. Nevertheless, monitoring of cell morphology changes indicated that exposure to BPA and its derivatives impaired neurite length in neuron-like cells. Thus, our findings provide insights into the molecular mechanisms of bisphenol-dependent neurotoxicity at low nanomolar levels and support the view that BPA substitutes may not be sufficiently safe for widespread use as industrial chemicals.
Reference Key
liang2020bisphenolfood Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Liang, Xiaoxing;Yin, Nuoya;Liang, Shengxian;Yang, Renjun;Liu, Shuyu;Lu, Yuanping;Jiang, Linshu;Zhou, Qunfang;Jiang, Guibin;Faiola, Francesco;
Journal food and chemical toxicology : an international journal published for the british industrial biological research association
Year 2020
DOI
S0278-6915(19)30805-1
URL
Keywords
human embryonic stem cells bisphenol a (bpa) derivatives human neural stem cells neural toxicity neurite length

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