Chemical proteomics profiling of proteasome activity.

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ID: 73147
2006
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Ranked #21 of 139 articles by views in methods in molecular biology (clifton, nj)

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Abstract
Proteolysis is a key mechanism for protein homeostasis in living cells. This process is effected by different classes of proteases. The proteasome is one of the most abundant and versatile proteases, bearing three different proteolytic active sites. The proteasome plays an important role in essential biological pathways such as antigen presentation, signal transduction, and cell-cycle control feedback loops. The aim of this work is to design novel chemical strategies for capturing, detection, identification, and quantification--in one word, profiling--the active protease fractions of interest, in cells of different phenotypes. Here, a set of chemistry-based functional proteomics techniques is demonstrated by profiling the multi-catalytic protease activities of the proteasome. Importantly, functional profiling is complementary to expression level profiling and is an indispensable parameter for better understanding of mechanisms underlying biological processes.
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verdoes2006chemicalmethods Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Verdoes, Martijn;Berkers, Celia R;Florea, Bogdan I;van Swieten, Paul F;Overkleeft, Herman S;Ovaa, Huib;
Journal methods in molecular biology (clifton, nj)
Year 2006
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Keywords
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