Oxidative Stress and Apoptotic Changes in Broiler Chicken Splenocytes Exposed to T-2 Toxin.

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ID: 72969
2019
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Abstract
T-2 toxin is a trichothecene mycotoxin produced by fungi which are known to contaminate cereals, especially in wheat and corn. T-2 toxin is known to cause a range of toxic effects in humans and animals, including immunosuppression and carcinogenesis. Although the effects of T-2 toxin on condition of chickens' spleens have been reported, there has been no systematic study of damage to the spleen of broiler chickens exposed to T-2 toxin. The purpose of the present study was to assess the effects of T-2 toxin on pathology, rates of apoptosis, oxidative stress, and T-lymphocyte subsets in the spleen of broiler chickens. One hundred and twenty male broiler chickens were randomly assigned to one of four groups (30 birds per group), fed 0 mg/kg (control), 0.5 mg/kg, 1 mg/kg, or 2 mg/kg T-2 toxin, respectively. After 21 days, chickens exposed to T-2 toxin demonstrated decreased relative weight and size of the spleen, increased percentage of apoptotic splenocytes, and evident lesions. Concentrations of reactive oxygen species and MDA content increased in splenocytes during T-2 toxin treatments, whereas activities of SOD, CAT, and GSH-PX decreased. The ratio of CD4+/CD8+ T cells also decreased as the dose of T-2 toxin increased. Overall, these results suggest that T-2 toxin causes oxidative stress, leading to increased rates of splenocyte apoptosis and might impair the splenic immune function of broiler chickens.
Reference Key
chen2019oxidativebiomed Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Chen, Yuqi;Han, Shunshun;Wang, Yan;Li, Diyan;Zhao, Xiaoling;Zhu, Qing;Yin, Huadong;
Journal BioMed research international
Year 2019
DOI
10.1155/2019/5493870
URL
Keywords
lignocellulosic biomass anaerobic co-digestion solid-state fermentation poultry manure

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