Subchronic exposure to cellulose nanofibrils induces nutritional risk by non-specifically reducing the intestinal absorption.

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ID: 70881
2020
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Abstract
Previous studies of cellulose nanofibrils (CNF) in decreasing fat absorption and glucose release suggested their potential application as food additives or supplements in diets containing high contents of fat and sugars. However, the long-term effects of CNF uptake remained unknown. The purpose of this study was to determine the effects of subchronic oral CNF consumption on various health aspects of Western diets (WD)-fed mice. The results demonstrated that CNF decreased fat absorption in the jejunum and attenuated WD-induced fatty liver, but slightly decreased lean body mass and affected glucose homeostasis. Additional in vivo studies showed that CNF decreased the intestinal absorption. The in vitro studies suggested that CNF did not decrease the viability of any cells used; however, they prevented epithelial and T cells, but not macrophages, from accessing the viability dye. Taken together, CNF decreased the intestinal absorption non-specifically, which might lead to nutritional risks after long-term exposure.
Reference Key
chen2020subchroniccarbohydrate Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Chen, Yingjia;Lin, Yu-Ju;Nagy, Tamas;Kong, Fanbin;Guo, Tai L;
Journal Carbohydrate polymers
Year 2020
DOI
S0144-8617(19)31204-4
URL
Keywords
toxicity intestine cellulose nanofibrils (cnf) fat glucose homeostasis

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