Delivery of Iron Oxide Nanoparticles into Primordial Germ Cells in Sturgeon.

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ID: 70014
2019
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Abstract
Nanoparticles are finding increasing applications in diagnostics, imaging and therapeutics in medicine. Iron oxide nanoparticles (IONs) have received significant interest of scientific community due to their distinctive properties. For the first time, we have delivered IONs into germ cells in any species. Our results showed that sturgeon primordial germ cells (PGCs) delivered with IONs could be detected until seven days post fertilization (dpf) under fluorescent microscope and at 22 dpf by micro-CT. Delivery of IONs into cells could be helpful for studying germ cell biology and the improvement of germ cell-based bio-technologies as isolation of PGCs using magnetic activated cell sorting or application of hyperthermia for a host sterilization purpose. Intriguingly, in our study, we did not find any toxic effects of IONs on the survival and hatching rates of sturgeon embryos when compared with embryos injected with FITC-dextran only.
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baloch2019deliverybiomolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Baloch, Abdul Rasheed;Fučíková, Michaela;Rodina, Marek;Metscher, Brian;Tichopád, Tomáš;Shah, Mujahid Ali;Franěk, Roman;Pšenička, Martin;
Journal Biomolecules
Year 2019
DOI
E333
URL
Keywords
caviar sterilization iron oxide nanoparticles hyperthermia acipenser micro-ct magnetic nanoparticles ph-responsive doxorubicin drug carrier iron oxide κ-carrageenan artificial neural networks ball tracking and trajectory prediction table-tennis robots

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