Engineering oxygen nanobubbles for the effective reversal of hypoxia.

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ID: 68332
2018
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Abstract
Hypoxia, which results from an inadequate supply of oxygen, is a major cause of concern in cancer therapy as it is associated with a reduction in the effectiveness of chemotherapy and radiotherapy in cancer treatment. Overexpression and stabilization of hypoxia-inducible factor 1α (HIF-1α) protein in tumours, due to hypoxia, results in poor prognosis and increased patient mortality. To increase oxygen tension in hypoxic areas, micro- and nanobubbles have been investigated by various researchers. In the present research, lipid-shelled oxygen nanobubbles (ONBs) were synthesized through a sonication method to reverse hypoxic conditions created in a custom-made hypoxic chamber. Release of oxygen gas from ONBs in deoxygenated water was evaluated by measuring dissolved oxygen. Hypoxic conditions were evaluated by performing in vitro experiments on MDA-MB231 breast cancer cells through the expression of HIF-1α and the fluorescence of image-iT™ hypoxia reagent. The results indicated the degradation of HIF-1α after the introduction of ONBs. We propose that ONBs are successful in reversing hypoxia, downregulating HIF-1α, and improving cellular conditions, leading to further medical applications.
Reference Key
khan2018engineeringartificial Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Khan, Muhammad Saad;Hwang, Jangsun;Seo, Youngmin;Shin, Kyusoon;Lee, Kyungwoo;Park, Chanhwi;Choi, Yonghyun;Hong, Jong Wook;Choi, Jonghoon;
Journal artificial cells, nanomedicine, and biotechnology
Year 2018
DOI
10.1080/21691401.2018.1492420
URL
Keywords
Hypoxia oxygen nanobubbles hif-1α mda-mb231

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