Discovery of disease- and drug-specific pathways through community structures of a literature network.

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ID: 67049
2019
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Abstract
In light of the massive growth of the scientific literature, text mining is increasingly used to extract biological pathways. Though multiple tools explore individual connections between genes, diseases, and drugs, few extensively synthesize pathways for specific diseases and drugs.Through community detection of a literature network, we extracted 3,444 functional gene groups that represented biological pathways for specific diseases and drugs. The network linked Medical Subject Headings (MeSH) terms of genes, diseases, and drugs that co-occurred in publications. The resulting communities detected highly associated genes, diseases, and drugs. These significantly matched current knowledge of biological pathways and predicted future ones in time-stamped experiments. Likewise, disease- and drug-specific communities also recapitulated known pathways for those given diseases and drugs. Moreover, diseases sharing communities had high comorbidity with each other and drugs sharing communities had many common side effects, consistent with related mechanisms. Indeed, the communities robustly recovered mutual targets for drugs (AUROC = 0.75) and shared pathogenic genes for diseases (AUROC = 0.82). These data show that literature communities inform not just known biological processes but also suggest novel disease- and drug-specific mechanisms that may guide disease gene discovery and drug repurposing.Application tools are available at http://meteor.lichtargelab.org.Supplementary data are available at Bioinformatics online.
Reference Key
pham2019discoverybioinformatics Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Pham, Minh;Wilson, Stephen;Govindarajan, Harikumar;Lin, Chih-Hsu;Lichtarge, Olivier;
Journal Bioinformatics
Year 2019
DOI
btz857
URL
Keywords
magnetic resonance spectroscopy elastography high-density emg laser diffraction mechanomyography skeletal muscle fatigue palliative care consensus intestinal obstruction neoplasm metastasis ascites peritoneal neoplasms

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