Combination of Colloidal Silicon Dioxide with Spray-Dried Solid Dispersion to Facilitate Discharge from an Agitated Dryer.

Clicks: 433
ID: 66463
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #5 of 79 articles by views in aaps pharmscitech

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
A feasibility evaluation of the addition of fumed silica (SiO) into an agitated dryer to aid spray-dried solid dispersion intermediate (SDSDi) flow during secondary drying and discharge is described. The quantity of SiO to enhance the flow character of SDSDi was assessed by measuring particle size distribution, bulk density, and flow-through-an-orifice. Results indicate that the addition of the SiO did not alter the drying kinetics and did not impact the bulk particle size distribution of the SDSDi. While bulk density of SDSDi increased with the addition of SiO, the flow, and thus the recovery of the SDSDi-SiO batch from the secondary dryer, was significantly higher than that for the intermediate alone. Imaging indicated uniform distribution of SiO in the bulk powder and coating on intermediate particles. Premixing and co-sieving of the SiO with a portion of pre-dry SDSDi promotes the uniform distribution of SiO within the bulk powder bed.
Reference Key
lee2019combinationaaps Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Lee, Yung-Chi;McNevin, Michael;Ikeda, Craig;Chouzouri, Georgia;Moser, Justin;Harris, David;Howell, Logan;
Journal aaps pharmscitech
Year 2019
DOI
10.1208/s12249-019-1392-1
URL
Keywords
spray drying powder flow agitation dryer secondary drying

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.