Bioactive Dietary VDR Ligands Regulate Genes Encoding Biomarkers of Skin Repair That Are Associated with Risk for Psoriasis.

Clicks: 396
ID: 66097
2018
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #32 of 376 articles by views in Nutrients

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 376 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Treatment with 1,25-dihydroxyvitamin D₃ (1,25D) improves psoriasis symptoms, possibly by inducing the expression of late cornified envelope ()3 genes involved in skin repair. In psoriasis patients, the majority of whom harbor genomic deletion of and (), we propose that certain dietary analogues of 1,25D activate the expression of residual genes to compensate for the loss of / in the deletant genotype. Herein, human keratinocytes (HEKn) homozygous for were treated with docosahexaenoic acid (DHA) and curcumin, two low-affinity, nutrient ligands for the vitamin D receptor (VDR). DHA and curcumin induce the expression of / mRNAs at concentrations corresponding to their affinity for VDR. Moreover, immunohistochemical quantitation revealed that the treatment of keratinocytes with DHA or curcumin stimulates protein expression, while simultaneously opposing the tumor necrosis factor-alpha (TNFα)-signaled phosphorylation of mitogen activated protein (MAP) kinases, p38 and Jun amino-terminal kinase (JNK), thereby overcoming inflammation biomarkers elicited by TNFα challenge. Finally, DHA and curcumin modulate two transcription factors relevant to psoriatic inflammation, the activator protein-1 factor Jun B and the nuclear receptor NR4A2/NURR1, that is implicated as a mediator of VDR ligand-triggered gene control. These findings provide insights into the mechanism(s) whereby dietary VDR ligands alter inflammatory and barrier functions relevant to skin repair, and may provide a molecular basis for improved treatments for mild/moderate psoriasis.
Reference Key
karrys2018bioactivenutrients Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Karrys, Amitis;Rady, Islam;Chamcheu, Roxane-Cherille N;Sabir, Marya S;Mallick, Sanchita;Chamcheu, Jean Christopher;Jurutka, Peter W;Haussler, Mark R;Whitfield, G Kerr;
Journal Nutrients
Year 2018
DOI
E174
URL
http://www.mdpi.com/2072-6643/10/2/174
Keywords
curcumin nutraceuticals differentiation vitamin d receptor activator protein-1 docosahexaenoic acid epidermis keratinocytes late cornified envelope genes psoriasis treatment continuance intention perceived value relationship quality e-tourism information system quality Statistical Analysis chloride durability long-term behaviour offshore concrete modal analysis hydraulic turbine natural frequencies strain gauges

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.