Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants

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ID: 65531
2018
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Abstract
Prostate cancer (PrCa) involves a large heritable genetic component. Here, the authors perform multivariate fine-mapping of known PrCa GWAS loci, identifying variants enriched for biological function, explaining more familial relative risk, and with potential application in clinical risk profiling.
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dadaev2018finemappingnature Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Dadaev, Tokhir;Saunders, Edward J.;Newcombe, Paul J.;Anokian, Ezequiel;Leongamornlert, Daniel A.;Brook, Mark N.;Cieza-Borrella, Clara;Mijuskovic, Martina;Wakerell, Sarah;Olama, Ali Amin Al;Schumacher, Fredrick R.;Berndt, Sonja I.;Benlloch, Sara;Ahmed, Mahbubl;Goh, Chee;Sheng, Xin;Zhang, Zhuo;Muir, Kenneth;Govindasami, Koveela;Lophatananon, Artitaya;Stevens, Victoria L.;Gapstur, Susan M.;Carter, Brian D.;Tangen, Catherine M.;Goodman, Phyllis;Thompson, Ian M.;Batra, Jyotsna;Chambers, Suzanne;Moya, Leire;Clements, Judith;Horvath, Lisa;Tilley, Wayne;Risbridger, Gail;Gronberg, Henrik;Aly, Markus;Nordström, Tobias;Pharoah, Paul;Pashayan, Nora;Schleutker, Johanna;Tammela, Teuvo L. J.;Sipeky, Csilla;Auvinen, Anssi;Albanes, Demetrius;Weinstein, Stephanie;Wolk, Alicja;Hakansson, Niclas;West, Catharine;Dunning, Alison M.;Burnet, Neil;Mucci, Lorelei;Giovannucci, Edward;Andriole, Gerald;Cussenot, Olivier;Cancel-Tassin, Géraldine;Koutros, Stella;Freeman, Laura E. Beane;Sorensen, Karina Dalsgaard;Orntoft, Torben Falck;Borre, Michael;Maehle, Lovise;Grindedal, Eli Marie;Neal, David E.;Donovan, Jenny L.;Hamdy, Freddie C.;Martin, Richard M.;Travis, Ruth C.;Key, Tim J.;Hamilton, Robert J.;Fleshner, Neil E.;Finelli, Antonio;Ingles, Sue Ann;Stern, Mariana C.;Rosenstein, Barry;Kerns, Sarah;Ostrer, Harry;Lu, Yong-Jie;Zhang, Hong-Wei;Feng, Ninghan;Mao, Xueying;Guo, Xin;Wang, Guomin;Sun, Zan;Giles, Graham G.;Southey, Melissa C.;MacInnis, Robert J.;FitzGerald, Liesel M.;Kibel, Adam S.;Drake, Bettina F.;Vega, Ana;Gómez-Caamaño, Antonio;Fachal, Laura;Szulkin, Robert;Eklund, Martin;Kogevinas, Manolis;Llorca, Javier;Castaño-Vinyals, Gemma;Penney, Kathryn L.;Stampfer, Meir;Park, Jong Y.;Sellers, Thomas A.;Lin, Hui-Yi;Stanford, Janet L.;Cybulski, Cezary;Wokolorczyk, Dominika;Lubinski, Jan;Ostrander, Elaine A.;Geybels, Milan S.;Nordestgaard, Børge G.;Nielsen, Sune F.;Weisher, Maren;Bisbjerg, Rasmus;Røder, Martin Andreas;Iversen, Peter;Brenner, Hermann;Cuk, Katarina;Holleczek, Bernd;Maier, Christiane;Luedeke, Manuel;Schnoeller, Thomas;Kim, Jeri;Logothetis, Christopher J.;John, Esther M.;Teixeira, Manuel R.;Paulo, Paula;Cardoso, Marta;Neuhausen, Susan L.;Steele, Linda;Ding, Yuan Chun;Ruyck, Kim De;Meerleer, Gert De;Ost, Piet;Razack, Azad;Lim, Jasmine;Teo, Soo-Hwang;Lin, Daniel W.;Newcomb, Lisa F.;Lessel, Davor;Gamulin, Marija;Kulis, Tomislav;Kaneva, Radka;Usmani, Nawaid;Slavov, Chavdar;Mitev, Vanio;Parliament, Matthew;Singhal, Sandeep;Claessens, Frank;Joniau, Steven;Broeck, Thomas Van den;Larkin, Samantha;Townsend, Paul A.;Aukim-Hastie, Claire;Gago-Dominguez, Manuela;Castelao, Jose Esteban;Martinez, Maria Elena;Roobol, Monique J.;Jenster, Guido;Schaik, Ron H. N. van;Menegaux, Florence;Truong, Thérèse;Koudou, Yves Akoli;Xu, Jianfeng;Khaw, Kay-Tee;Cannon-Albright, Lisa;Pandha, Hardev;Michael, Agnieszka;Kierzek, Andrzej;Thibodeau, Stephen N.;McDonnell, Shannon K.;Schaid, Daniel J.;Lindstrom, Sara;Turman, Constance;Ma, Jing;Hunter, David J.;Riboli, Elio;Siddiq, Afshan;Canzian, Federico;Kolonel, Laurence N.;Marchand, Loic Le;Hoover, Robert N.;Machiela, Mitchell J.;Kraft, Peter;Consortium, The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome);Freedman, Matthew;Wiklund, Fredrik;Chanock, Stephen;Henderson, Brian E.;Easton, Douglas F.;Haiman, Christopher A.;Eeles, Rosalind A.;Conti, David V.;Kote-Jarai, Zsofia;
Journal Nature communications
Year 2018
DOI
DOI not found
URL
http://link.springer.com/article/10.1038/s41467-018-04109-8
Keywords
Science Immunologic diseases. Allergy environmental sciences

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