The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: the AGE at Heart trial

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ID: 6527
2016
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Abstract
The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: the AGE at Heart trial Karin Ried,1–3 Nikolaj Travica,1 Avni Sali1 1National Institute of Integrative Medicine, Melbourne, 2Faculty of Health Science and Medicine, Bond University, Gold Coast, 3Department of General Practice, University of Adelaide, Adelaide, Australia Background: Hypertension affects 30% of adults worldwide. Garlic supplements have shown promise in the treatment of uncontrolled hypertension, and the mechanism of action is biologically plausible. Our trial is the first to assess the effect of aged garlic extract on central blood pressure and arterial stiffness, regarded as important risk factors for cardiovascular morbidity. Subjects and methods: A total of 88 general practice patients and community members with uncontrolled hypertension completed a double-blind randomized placebo-controlled trial of 12 weeks investigating the effect of daily intake of aged garlic extract (1.2 g containing 1.2 mg S-allylcysteine) or placebo on blood pressure, and secondary outcome measures of central-hemodynamics and other cardiovascular markers, including cholesterol, homocysteine, platelet function, and inflammatory markers. Results: Mean blood pressure was significantly reduced by 5.0±2.1 mmHg (P
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karin2016theintegrated Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Karin Ried;Nikolaj Travica;Avni Sali and
Journal integrated blood pressure control
Year 2016
DOI
10.2147/IBPC.S93335
URL
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