Copper-catalyzed enantioselective alkynylation of pyrazole-4,5-diones with terminal alkynes.

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ID: 64663
2019
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Abstract
A copper-catalyzed enantioselective alkynylation between terminal alkynes and pyrazole-4,5-diones has been developed. With 2.5 mol% CuI and 3 mol% chiral ligand L15, chiral propargylic alcohols bearing a pyrazolone motif were produced in 82-99% yield and up to 98% ee. Moreover, both enantiomers of the chiral propargylic alcohols were obtained with ligands L12 and L15, respectively.
Reference Key
lu2019coppercatalyzedchemical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Lu, Jian;Luo, Ling-Shan;Sha, Feng;Li, Qiong;Wu, Xin-Yan;
Journal Chemical communications (Cambridge, England)
Year 2019
DOI
10.1039/c9cc05252f
URL
Keywords
uplc-ms/ms monosaccharide composition polyporus umbellatus polysaccharide pre-column derivation

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