Melognine, a novel monoterpenoid indole alkaloid from that induce apoptosis in BT549 cells.
Clicks: 293
ID: 64579
2019
Article Quality & Performance Metrics
Overall Quality
Improving Quality
0.0
/100
Combines engagement data with AI-assessed academic quality
Reader Engagement
Steady Performance
70.6
/100
292 views
234 readers
Trending
AI Quality Assessment
Not analyzed
Abstract
A novel monoterpenoid indole alkaloid, melognine () possessing an unprecedented skeleton with a 6/6/5/5/6/6 hexatomic rearranged ring system was isolated from the stems of . The structure with absolute configuration of was established by extensive spectroscopic analyses and quantum ECD calculations. Melognine showed significant cytotoxicity on human breast cancer BT549 cells with an IC value of 1.49 μM by MTT assay. Further mechanism of action study indicated that melognine demonstrated the ability to induce apoptosis by activation of caspase-3 and p53, and downregulation of Bcl-2 in BT549 cells.
| Reference Key |
zhou2019melogninenatural
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Zhou, Jie;Du, Si-Yu;Fang, Zhong-Ying;Feng, Jin-Hong; |
| Journal | Natural product research |
| Year | 2019 |
| DOI |
10.1080/14786419.2019.1682579
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.