Melognine, a novel monoterpenoid indole alkaloid from that induce apoptosis in BT549 cells.

Clicks: 338
ID: 64579
2019
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Abstract
A novel monoterpenoid indole alkaloid, melognine () possessing an unprecedented skeleton with a 6/6/5/5/6/6 hexatomic rearranged ring system was isolated from the stems of . The structure with absolute configuration of was established by extensive spectroscopic analyses and quantum ECD calculations. Melognine showed significant cytotoxicity on human breast cancer BT549 cells with an IC value of 1.49 μM by MTT assay. Further mechanism of action study indicated that melognine demonstrated the ability to induce apoptosis by activation of caspase-3 and p53, and downregulation of Bcl-2 in BT549 cells.
Reference Key
zhou2019melogninenatural Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zhou, Jie;Du, Si-Yu;Fang, Zhong-Ying;Feng, Jin-Hong;
Journal Natural product research
Year 2019
DOI
10.1080/14786419.2019.1682579
URL
Keywords
Cytotoxicity apoptosis melodinus fusiformis monoterpenoid indole alkaloid

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