Overview of the epidemiology and the threat of Klebsiella pneumoniae carbapenemases (KPC) resistance

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ID: 6433
2012
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Abstract
Overview of the epidemiology and the threat of Klebsiella pneumoniae carbapenemases (KPC) resistance Luke F Chen,1–4 Deverick J Anderson,1–4 David L Paterson51Duke Program for Infection Prevention and Healthcare Epidemiology, 2Duke Infection Control Outreach Network, 3Duke University Prevention Epicenter Program, 4Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, NC, USA; 5University of Queensland Centre for Clinical Research (UQCCR), Royal Brisbane and Women's Hospital Campus, Brisbane, AustraliaAbstract: Klebsiella pneumoniae carbapenemases (KPCs) confer resistance to nearly all ß-lactams. This broad-spectrum drug resistance mechanism has rapidly spread in the United States and is reportedly increasing elsewhere in the world. Thus, the emergence of KPC resistance is a major threat to global health. This article reviews the epidemiology and provides an overview of the dissemination of KPC-producing organisms.Keywords: beta-lactam resistance, carbapenemase, drug resistance, epidemiology, treatment failure
Reference Key
luke2012overviewinfection Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Luke F Chen;Deverick J Anderson;David L Paterson and
Journal Infection and drug resistance
Year 2012
DOI
10.2147/IDR.S26613
URL
Keywords
Infectious and parasitic diseases

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