Asymmetric synthesis of atropisomeric pyrazole via an enantioselective reaction of azonaphthalene with pyrazolone.

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ID: 64014
2019
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Abstract
The first catalytic asymmetric reaction of azonaphthalene with pyrazolone has been established. A wide range of axially chiral pyrazole derivatives have been achieved in good yields (68-99%) with excellent enantioselectivities (83-98% ee) by utilizing chiral phosphoric acid as a catalyst. This strategy provides an efficient and facile approach for the construction of axially chiral pyrazole derivatives. Theoretical calculations were carried out to elucidate the origins of enantioselectivity.
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yuan2019asymmetricchemical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yuan, Huijun;Li, Yao;Zhao, Hanhui;Yang, Zhihong;Li, Xin;Li, Wenjun;
Journal Chemical communications (Cambridge, England)
Year 2019
DOI
10.1039/c9cc06360a
URL
Keywords
toxicity biological azoles microbial inhibition

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