The influence of freezing rates on bovine pericardium tissue Freeze-drying

Clicks: 346
ID: 63862
2009
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Ranked #8 of 64 articles by views in brazilian archives of biology and technology

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Abstract
The bovine pericardium has been used as biomaterial in developing bioprostheses. Freeze-drying is a drying process that could be used for heart valve's preservation. The maintenance of the characteristics of the biomaterial is important for a good heart valve performance. This paper describes the initial step in the development of a bovine pericardium tissue freeze-drying to be used in heart valves. Freeze-drying involves three steps: freezing, primary drying and secondary drying. The freezing step influences the ice crystal size and, consequently, the primary and secondary drying stages. The aim of this work was to investigate the influence of freezing rates on the bovine pericardium tissue freeze-drying parameters. The glass transition temperature and the structural behaviour of the lyophilized tissues were determined as also primary and secondary drying time. The slow freezing with thermal treatment presented better results than the other freeze-drying protocols.
O pericárdio bovino é um material utilizado na fabricação de biopróteses. A liofilização é um método de secagem que vem sendo estudado para a conservação de válvulas cardíacas. A preservação das características do biomaterial é de fundamental importância no bom funcionamento das válvulas. Este artigo é a primeira etapa do desenvolvimento do ciclo de liofilização do pericárdio bovino. Liofilização é o processo de secagem no qual a água é removida do material congelado por sublimação e desorção da água incongelável, sob pressão reduzida. O congelamento influencia o tamanho do cristal de gelo e, consequentemente, a secagem primária e secundária. O objetivo deste estudo foi verificar a influência das taxas de congelamento nos parâmetros de liofilização do pericárdio bovino. Determinou-se a temperatura de transição vítrea e o comportamento estrutural do pericárdio bovino liofilizado. Determinou-se o tempo da secagem primária e secundária. O protocolo de liofilização utilizando-se congelamento lento com annealing apresentou os melhores resultados.
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borgognoni2009thebrazilian Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Borgognoni, Camila Figueiredo;Junior, Virgilio Tattini;Ayrosa, Ana Maria Irene Bartolomeu;Polakiewicz, Bronislaw;Leirner, Adolfo Alberto;Maizato, Marina Junko Shiotsu;Higa, Olga Zazuco;Beppu, Marisa Masumi;Pitombo, Ronaldo Nogueira de Moraes;
Journal brazilian archives of biology and technology
Year 2009
DOI
DOI not found
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000600021
Keywords
Biotechnology general works

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