Horizontal gene transfer in the human gastrointestinal tract: potential spread of antibiotic resistance genes

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ID: 6386
2014
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Abstract
Horizontal gene transfer in the human gastrointestinal tract: potential spread of antibiotic resistance genes Jennifer R HuddlestonBiology Department, Abilene Christian University, Abilene, TX, USAAbstract: Bacterial infections are becoming increasingly difficult to treat due to widespread antibiotic resistance among pathogens. This review aims to give an overview of the major horizontal transfer mechanisms and their evolution and then demonstrate the human lower gastrointestinal tract as an environment in which horizontal gene transfer of resistance determinants occurs. Finally, implications for antibiotic usage and the development of resistant infections and persistence of antibiotic resistance genes in populations as a result of horizontal gene transfer in the large intestine will be discussed.Keywords: gut microbiome, conjugation, natural transformation, transduction
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jennifer2014horizontalinfection Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jennifer R Huddleston and
Journal Infection and drug resistance
Year 2014
DOI
10.2147/IDR.S48820
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