Selective Phosphorylation of Akt/Protein-Kinase B Isoforms in Response to Dietary Cues.

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ID: 63626
2019
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Ranked #4 of 9 articles by views in Frontiers in cell and developmental biology

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Abstract
A calorie-rich diet is one reason for the continuous spread of metabolic syndromes in western societies. Smart food design is one powerful tool to prevent metabolic stress, and the search for suitable bioactive additives is a continuous task. The nutrient-sensing insulin pathway is an evolutionary conserved mechanism that plays an important role in metabolism, growth and development. Recently, lipid cues capable to stimulate insulin signaling were identified. However, the mechanistic base of their activity remains obscure to date. We show that specific Akt/Protein-kinase B isoforms are responsive to different calorie-rich diets, and potentiate the activity of the cellular insulin cascade. Our data add a new dimension to existing models and position as a powerful tool to study the relation between dietary lipid cues and the insulin-induced cellular signal pathway.
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trautenberg2019selectivefrontiers Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Trautenberg, Laura Christin;Prince, Elodie;Maas, Cornelia;Beier, Nora;Honold, Freya;Grzybek, Michal;Brankatschk, Marko;
Journal Frontiers in cell and developmental biology
Year 2019
DOI
10.3389/fcell.2019.00206
URL
Keywords
insulin signaling drosophila akt saccharomyces cerevisiae akt phosphorylation cystobasidium oligophagum pkb yeast lipids

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