[Application of proteomics and metabolomics in microbial metabolic engineering].

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ID: 63071
2019
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Abstract
Construction of microbial cell factories is a feasible strategy for the sustainable production of chemicals, biofuels, and pharmaceutical molecules. However, the complex metabolism and rigid regulation of microbes hinders the efficient synthesis of the products of interest. Proteomics and metabolomics analyze enzymes and metabolites in terms of systems biology, thus unraveling complex biological systems and providing significant clues for microbial metabolic engineering. Here, the applications of proteomics and metabolomics in microbial metabolic engineering were reviewed, including the construction of genome-scale metabolic models, optimization of microbial product synthesis, guidance of microbial stress tolerance engineering, and prediction of rate-limiting steps. In addition, proteomics and metabolomics could be employed to explore secondary metabolic pathways in plants, to reveal novel genes or pathways for microbial synthesis of natural products. Finally, the development of bio-big data was discussed.
Reference Key
yu2019applicationse Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yu, Wei;Gao, Jiaoqi;Zhou, Yongjin;
Journal se pu = chinese journal of chromatography
Year 2019
DOI
10.3724/SP.J.1123.2019.04026
URL
Keywords
Proteomics review metabolomics genome-scale metabolic model microbial metabolic engineering plant secondary metabolism

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