Post-influenza aspergillosis, do not underestimate influenza B

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ID: 6285
2017
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Abstract
Post-influenza aspergillosis, do not underestimate influenza B Eric FL Nulens,1 Marc JC Bourgeois,2 Marijke BML Reynders1 1Laboratory Medicine, Medical Microbiology, 2Department of Intensive Care, Algemeen Ziekenhuis Sint-Jan Brugge-Oostende AV, Brugge, Belgium Abstract: Our objective is to highlight and focus on post-influenza aspergillosis, triggered by influenza B virus. This relatively new clinical entity is often associated with a fulminant course of respiratory decline and high mortality. A 51-year immunocompetent woman, without any medical history or risk factors for developing a complicated influenza infection, was admitted to the intensive care unit. During admission, she presented with an afebrile flu-like syndrome, myocarditis, rhabdomyolysis, multiple organ failure, and evolved to severe respiratory distress. The broncho-alveolar lavage contained influenza B RNA, and the culture revealed Aspergillus fumigatus. Despite maximal organ support, immunoglobulin, antiviral and antifungal therapy, the patient died. This case demonstrates that influenza B virus may be life threatening even to immunocompetent adults and may trigger an invasive Aspergillus superinfection. Keywords: post-influenza aspergillosis, influenza B, invasive pulmonary aspergillosis, rhabdomyolysis, ARDS, antiviral therapy 
Reference Key
eric2017postinfluenzainfection Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Eric FL Nulens;Marc JC Bourgeois;Marijke BML Reynders and
Journal Infection and drug resistance
Year 2017
DOI
10.2147/IDR.S122390
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