Urtica dioica L. inhibits proliferation and enhances cisplatin cytotoxicity in NSCLC cells via Endoplasmic Reticulum-stress mediated apoptosis.

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ID: 62672
2019
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Abstract
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and the ineffectiveness of the current therapies seriously limits the survival rate of NSCLC patients. In the search for new antitumor agents, nature has played a pivotal role providing a variety of molecules, which are likely to exert selective anti-tumour properties. Herein, we investigated the antiproliferative potential of Urtica dioica L. extract (UD) against NSCLC cell models with low sensitivity to cisplatin, a cytotoxic agent largely employed to cure NSCLCs. UD inhibited cell proliferation in the selected cells, while no toxic effects were observed in normal lung cells. Furthermore, the co-treatment of UD and cisplatin notably sensitised NSCLC cells to cisplatin. Mechanistically, we discovered that UD-promoted endoplasmic reticulum (ER) stress via activation of the growth arrest and DNA damage-inducible gene 153 (GADD153) triggering apoptosis. We also performed an extensive NMR analysis of UD, identifying rutin and oxylipins as the main secondary metabolites present in the mixture. Additionally, we discovered that an oxylipins' enriched fraction contributes to the antiproliferative activity of the plant extract. In the future, this study may provide new chemical scaffolds for the design of anti-cancer agents that target NSCLCs with low sensitivity to cisplatinum.
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dabrosca2019urticascientific Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors D'Abrosca, Brigida;Ciaramella, Vincenza;Graziani, Vittoria;Papaccio, Federica;Della Corte, Carminia Maria;Potenza, Nicoletta;Fiorentino, Antonio;Ciardiello, Fortunato;Morgillo, Floriana;
Journal Scientific reports
Year 2019
DOI
10.1038/s41598-019-41372-1
URL
Keywords
antioxidant antidiabetic antithrombotic urtica dioica cistus creticus sideritis euobea antiatherogenic pasta

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