Naturally occurring genotypic drug-resistant mutations of HBV in Huzhou, China: a single-center study

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2017
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Abstract
Naturally occurring genotypic drug-resistant mutations of HBV in Huzhou, China: a single-center study Fuchu Qian,1 Weihua Zou,2 Jiqu Qin,1 Dongli Li1 1Huzhou Key Laboratory of Molecular Medicine, 2Department of Laboratory Medicine, Huzhou Central Hospital, Huzhou, ChinaChina is an area with highly endemic hepatitis B virus (HBV) infection, with an estimated 93 million HBV carriers, resulting in approximately 330,000 deaths annually.1 The predominant HBV genotypes in China are genotype B and C. Currently,  nucleos(t)ide analogs are used for anti-HBV treatment. However, prolonged antiviral therapy may lead to drug resistance, which is associated with mutations in the reverse transcriptase region of the HBV genome. Several studies have shown that drug-resistant mutations existed in treatment-naïve patients with chronic hepatitis B (CHB). However, the prevalence rates of natural drug-resistant mutations varied in different reports.2,3 Furthermore, the prevalence and clinical profile of natural drug-resistant mutations in CHB patients are not quite clear. Thus, the purpose of this study was to investigate the prevalence and clinical feature of natural drug-resistant mutations among treatmentnaïve CHB patients in a tertiary hospital in Huzhou, eastern China.
Reference Key
fuchu2017naturallyinfection Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Fuchu Qian;Weihua Zou;Jiqu Qin;Dongli Li and
Journal Infection and drug resistance
Year 2017
DOI
10.2147/IDR.S149992
URL
Keywords
eastern china hepatitis b virus mutationinfectious and parasitic diseases

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