Emergence and spread of worldwide Staphylococcus aureus clones among cystic fibrosis patients

Clicks: 254
ID: 6209
2018
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #1,244 of 1,693 articles by views in Infection and drug resistance

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 1,693 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Emergence and spread of worldwide Staphylococcus aureus clones among cystic fibrosis patients Katarzyna Garbacz,1 Lidia Piechowicz,2 Magdalena Podkowik,3 Aneta Mroczkowska,4 Joanna Empel,4 Jacek Bania3 1Department of Oral Microbiology, Medical University of Gdansk, Gdansk, Poland; 2Department of Medical Microbiology, Medical University of Gdansk, Gdansk, Poland; 3Department of Food Hygiene and Consumer Health Protection, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland; 4Department of Epidemiology and Clinical Microbiology, National Medicines Institute, Warsaw, Poland Background: The aim of this study was to assess the relatedness of molecular types of Staphylococcus aureus isolates colonizing cystic fibrosis (CF) patients with their antimicrobial resistance and prevalence of toxin genes. Methods: A total of 215 isolates from the airways of 107 patients with CF were tested for spa and SCCmec type, antimicrobial resistance and carriage of toxin genes. Results: t015, t084, t091, t700 and t002 were the largest group (approximately 25%) among all 69 identified spa types. Five new spa types, t14286, t14287, t14288, t14289 and t14290, were identified and registered. Isolates from CF patients were clustered into 11 multi-locus sequence typing clonal complexes, with CC30, CC22, CC97, CC45, CC15 and CC5 being the most frequent ones. Twelve (5.6%) methicillin-resistant S. aureus (MRSA) isolates and 102 (47.7%) multidrug-resistant isolates were identified, along with three SCCmec types (I, III and V). All isolates (both MRSA and methicillin-sensitive S. aureus) were Panton–Valentine leucocidin-negative, and 56.7% harbored egc genes. This was the first study documenting the presence of ST398-V-t571 livestock-associated MRSA in a European patient with CF. Conclusion: These findings imply that individuals with CF can also be colonized with animal-related ST398 MRSA, and justify constant monitoring of staphylococcal colonization and identification of epidemic S. aureus clones in this group. Keywords: Staphylococcus aureus, cystic fibrosis, ST398 MRSA, Panton–Valentine leukocidin, spa typing, MRSA
Reference Key
katarzyna2018emergenceinfection Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Katarzyna Garbacz;Lidia Piechowicz;Magdalena Podkowik;Aneta Mroczkowska;Joanna Empel;Jacek Bania and
Journal Infection and drug resistance
Year 2018
DOI
10.2147/IDR.S153427
URL
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.