Multidrug-resistant malaria and the impact of mass drug administration

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ID: 6203
2018
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Abstract
Multidrug-resistant malaria and the impact of mass drug administration Janie Anne Zuber, Shannon Takala-Harrison Division of Malaria Research, Institute for Global Health, University of Maryland School of Medicine, Baltimore, MD, USA Abstract: Based on the emergence and spread throughout the Greater Mekong Subregion (GMS) of multiple artemisinin-resistant lineages, the prevalence of multidrug resistance leading to high rates of artemisinin-based combination treatment failure in parts of the GMS, and the declining malaria burden in the region, the World Health Organization has recommended complete elimination of falciparum malaria from the GMS. Mass drug administration (MDA) is being piloted as one elimination intervention to be employed as part of this effort. However, concerns remain as to whether MDA might exacerbate the already prevalent problem of multidrug resistance in the region. In this review, we briefly discuss challenges of MDA, the use of MDA in the context of multidrug-resistant malaria, and the potential of different drug combinations and drug-based elimination strategies for mitigating the emergence and spread of resistance. Keywords: malaria, drug resistance, mass drug administration
Reference Key
janie2018multidrugresistantinfection Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Janie Anne Zuber;Shannon Takala-Harrison and
Journal Infection and drug resistance
Year 2018
DOI
10.2147/IDR.S123887
URL
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