A systematic review and meta-analysis on the use of prophylactic topical antibiotics for the prevention of uncomplicated wound infections

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ID: 6191
2018
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Abstract
A systematic review and meta-analysis on the use of prophylactic topical antibiotics for the prevention of uncomplicated wound infections Qiao-Jing Tong,1 Kimberly DP Hammer,2,3 Erika M Johnson,4 Milagros Zegarra,2,3 Michihiko Goto,5,6 Tze Shien Lo3,7 1Department of Infection Control, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; 2Research Service, Fargo VA Health Care System; 3Department of Internal Medicine, University of North Dakota, School of Medicine and Health Sciences, Fargo, ND, USA; 4Library Resources, University of North Dakota, School of Medicine and Health Sciences, Fargo, ND, USA; 5Center for Comprehensive Access & Delivery Research & Evaluation (CADRE), Iowa City VA Health Care System, West Iowa City, IA, USA; 6Department of Internal Medicine, University of Iowa, Carver College of Medicine, Iowa City, IA, USA; 7Infectious Disease Service, Fargo VA Health Care System, Fargo, ND, USA Background: The prescription of topical antibiotics for the prevention of infections in uncomplicated wounds is common. However, the efficacy is not well reported. Therefore, the objective of the study was to conduct a systematic review and meta-analysis of the available evidence on prevention of uncomplicated wound infections by prophylactic topical antibiotics. Materials and methods: The search included Pubmed, Google Scholar, SCOPUS, Embase, Cochrane, ClinicalTrials.gov, International Clinical Trials Registry Platform, National Technical Information Service, and the National Guidelines Clearinghouse. Results: We identified eight randomized controlled trials and four quasi-randomized trials that met the criteria for the systematic review. Of these trials, 11 studies were pooled for meta-analysis to compare the effects of topical antibiotics versus placebo and 4 studies were pooled for comparison of effects of topical antibiotics versus topical antiseptics on uncomplicated wounds. Fewer wound infections occurred in the topical antibiotic arms compared to placebo (pooled risk ratio: 0.57 [95% CI: 0.37 to 0.86]; p
Reference Key
qiaojing2018ainfection Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Qiao-Jing Tong;Kimberly DP Hammer;Erika M Johnson;Milagros Zegarra;Michihiko Goto;Tze Shien Lo and
Journal Infection and drug resistance
Year 2018
DOI
10.2147/IDR.S151293
URL
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