Antimicrobial use of reactive oxygen therapy: current insights

Clicks: 281
ID: 6175
2018
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Abstract
Antimicrobial use of reactive oxygen therapy: current insights Mohammad Yousef Memar,1 Reza Ghotaslou,2 Mohammad Samiei,3 Khosro Adibkia4 1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; 2Department of Microbiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; 3Faculity of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran; 4Research Center for Pharmaceutical Nanotechnology and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran Abstract: Infections caused by drug-resistant pathogens are a global public health problem. The introduction of a new antimicrobial strategy is an unavoidable option for the management of drug-resistant pathogens. Induction of high levels of reactive oxygen species (ROS) by several procedures has been extensively studied for the treatment of infections. In this article, the general aspects of ROS production and the common procedures that exert their antimicrobial effects due to ROS formation are reviewed. ROS generation is the antimicrobial mechanism of nanoparticles, hyperbaric oxygen therapy, medical honey, and photodynamic therapy. In addition, it is an alternative bactericidal mechanism of clinically traditional antibiotics. The development of ROS delivery methods with a desirable selectivity for pathogens without side effects for the host tissue may be a promising approach for the treatment of infections, especially those caused by drug-resistant organisms. Keywords: antibiotic resistance, infections, reactive oxygen species
Reference Key
mohammad2018antimicrobialinfection Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Mohammad Yousef Memar;Reza Ghotaslou;Mohammad Samiei;Khosro Adibkia and
Journal Infection and drug resistance
Year 2018
DOI
10.2147/IDR.S142397
URL
Keywords Keywords not found

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