First Synthesis for Bis-Spirothiazolidine Derivatives as a Novel Heterocyclic Framework and Their Biological Activity.

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ID: 61345
2019
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Abstract
Spirothiazolidines were versatile synthetic scaffold processing wide spectrum of biological interests involving potential anticancer activity.Report the first synthesis of Bis Spiro-thiazolidene as a novel heterocyclic ring system.One-pot three-component reaction include condensation of p-phenyllene diamine; cyclohexanone and thioglycolic acid produced Spiro-thiazolidine 4 which undergo further condensation with cyclohexanone and thioglycolic acid with eqiumolar ratio to introduce Bis-Spiothiazolidine 5 as a first synthesis. Also;bis spiro-thiazolidine arylidene derivatives 6‒13 were synthesized by reaction of Bis-Spiothiazolidine 5 with different aromatic benzaldehyde.Four compounds 13, 12, 9 and 11 have showed high significantly anticancer activity compared to Doxorubicin® (positive control) against Human liver carcinoma (HepG2) and human normal Retina pigmented epithelium (RPE-1) cell lines.The novel bis-spirothiazolidine deriviatives synthesized for the first time and showed excellent anticancer activities.
Reference Key
flefel2019firstmini Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Flefel, Eman M;Sofany, Walaa I;Awad, Hanem M;Shahat, Mahmoud El-;
Journal mini reviews in medicinal chemistry
Year 2019
DOI
10.2174/1389557519666190920114852
URL
Keywords
Antimicrobial activity anticancer activity hepg2 rpe-1 arylidene azaspiro[4.5]decan-3-one

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