Advancing metabolism research to overcome low litter survival in metabolically stressed mice.

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ID: 60362
2019
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Ranked #18 of 316 articles by views in american journal of physiology endocrinology and metabolism

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Abstract
Elucidating the mechanism underlying the transmission of metabolic disease to subsequent generations requires robust preclinical mouse breeding strategies. Western diets rich in fat and carbohydrates are contributing factors in the rise of diabetes and obesity rates worldwide. Therefore, determining the impact of Western diets consumed by parents on offspring and future generations is critical for understanding the perpetuation of these diseases. Specifically, epigenetic regulation and transgenerational inheritance of metabolic disease is an emerging field of study requiring robust murine models. However, a major challenge to transgenerational studies is offspring mortality, exacerbated by maternal stress during pregnancy. Here, we describe a challenge experienced in our metabolic research in Western diet-fed female mice leading to the loss of litters via pup mortality and cannibalism by the mother. Furthermore, our study evaluates various breeding schemes with pregnancy efficiency and refined husbandry techniques to overcome pup mortality and infanticide, to characterize dams' and pups' metabolic characteristics, and to determine the impact on physiology of dams under detailed breeding schemes.
Reference Key
powell2019advancingamerican Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Powell, Catherine A;Choudhury, Mahua;
Journal american journal of physiology endocrinology and metabolism
Year 2019
DOI
10.1152/ajpendo.00024.2019
URL
Keywords
metabolism breeding high-fat/high-fructose diet litter loss refined husbandry technique

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