Gene drives as a response to infection and resistance

Clicks: 194
ID: 5956
2019
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Abstract
Gene drives as a response to infection and resistance Tuna C Hayirli,1 Peter F Martelli2 1Harvard Medical School, Boston, MA, USA; 2Department of Healthcare Administration, Sawyer Business School, Suffolk University, Boston, MA, USA Abstract: Vector-borne infectious diseases continue to be a major threat to public health. Although some prevention and treatment modalities exist for these diseases, resistance to such modalities, exacerbated by global climate change, remains a fundamental challenge. Developments in genomic engineering technologies present a new front in battling vector-borne illnesses; however, there is a lack of consensus over the scope and consequences of these approaches. In this article, we use malaria as a case study to address the developments and controversies surrounding gene drives, a novel genomic engineering technology. We draw attention to the themes of infection control, resistance, and reversibility using a science and technology studies framework. Unlike other current prevention and treatment modalities, gene drives have the capacity to alter not only single organisms but also entire species and ecologies. Therefore, broader public and scientific engagement is needed to inform a more inclusive discussion between clinicians, researchers, policy makers, and society. Keywords: CRISPR, gene drive, gene editing, vector-borne disease, STS, imaginaries
Reference Key
tuna2019geneinfection Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Tuna C Hayirli;Peter F Martelli and
Journal Infection and drug resistance
Year 2019
DOI
10.2147/IDR.S187424
URL
Keywords Keywords not found

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