"Chemotherapy-periodized" Exercise to Accommodate for Cyclical Variation in Fatigue.

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ID: 59165
2019
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Abstract
The purpose of this study was to provide a rationale for 'chemotherapy-periodized' exercise by characterizing cyclical variations in fatigue and exercise response across a chemotherapy cycle and comparing exercise adherence during chemotherapy between a prescription that is periodized according to chemotherapy cycle length and a standard linearly progressed prescription.Women with breast cancer who were prescribed taxane-based chemotherapy were randomly assigned to a supervised aerobic and resistance exercise program following a chemotherapy-periodized exercise prescription (n=12) or to usual care during chemotherapy (n=15). Fatigue and steady state exercise responses were assessed in both groups prior to the first taxane treatment and across the third treatment (i.e., 0-3 days prior and 3-5 days after the third treatment, and 0-3 days prior to the fourth treatment) to assess cyclical variations. Adherence to the chemotherapy-periodized exercise prescription was compared to adherence to a standard linear prescription from a prior study in a similar population (n=51).Fatigue increased from baseline (marginal mean±standard error: 3.2±0.4) to prior to the third treatment (4.1±0.4, p=0.025), then peaked at 3-5 days after the third treatment (5.1±0.4, p=0.001), before recovering prior to the next treatment (4.3±0.5, p=0.021). The peak in fatigue at 3-5 days post-third treatment corresponded to a decrease in steady state exercise oxygen consumption (VO2) (p=0.013). Compared to a standard linear exercise prescription during chemotherapy, a chemotherapy-periodized exercise prescription resulted in higher attendance during the week after chemotherapy (57±30% vs 77±28%, p=0.04) and overall attendance (63+25% vs 78±23%, p=0.05).Fatigue and exercise VO2 vary across a chemotherapy cycle. A chemotherapy-periodized exercise prescription that accommodates cyclical variations in fatigue may increase adherence to supervised exercise.
Reference Key
kirkham2019chemotherapyperiodizedmedicine Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kirkham, Amy A;Bland, Kelcey A;Zucker, David S;Bovard, Joshua;Shenkier, Tamara;McKenzie, Donald C;Davis, Margot K;Gelmon, Karen A;Campbell, Kristin L;
Journal medicine and science in sports and exercise
Year 2019
DOI
10.1249/MSS.0000000000002151
URL
Keywords
exercise scoping review physiotherapy kettlebell

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